Assay Detail
Binding
CHEMBL3388378
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Non-competitive inhibition of mushroom tyrosinase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.52 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1275999 | GAMMA-THUJAPLICIN | — | 1 | 7.16 |
| CHEMBL48310 | HINOKITIOL | — | 1 | 7.05 |
| CHEMBL3343985 | — | — | 1 | 5.08 |
| CHEMBL1275969 | ALPHA-THUJAPLICIN | — | 1 | 5.02 |
| CHEMBL2110597 | TRIOLEIN | -1.0 | 1 | 4.52 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1275999 | GAMMA-THUJAPLICIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL48310 | HINOKITIOL | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3343985 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1275969 | ALPHA-THUJAPLICIN | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL2110597 | TRIOLEIN | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 53700.0 | nM | 4.27 |