Assay Detail
Functional
CHEMBL3388467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Venezuelan equine encephalitis virus TrD infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Venezuelan equine encephalitis virus |
| Cell Type | Vero 76 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Venezuelan equine encephalitis virus (CHEMBL613726) ↗| Type | ORGANISM |
| Organism | Venezuelan equine encephalitis virus |
Publication
Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.97 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3186763 | — | — | 1 | 7.40 |
| CHEMBL3183844 | — | — | 1 | 7.30 |
| CHEMBL1399083 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3186763 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3183844 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1399083 | — | EC50 | = | 600.0 | nM | 6.22 |