Assay Detail
Binding
CHEMBL3388490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrophotometry
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 7.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342603 | — | — | 1 | 8.00 |
| CHEMBL3343183 | — | — | 1 | 7.96 |
| CHEMBL3342605 | — | — | 1 | 7.89 |
| CHEMBL3342604 | — | — | 1 | 7.85 |
| CHEMBL3342432 | — | — | 1 | 7.82 |
| CHEMBL3342610 | — | — | 1 | 7.75 |
| CHEMBL3342431 | — | — | 1 | 7.72 |
| CHEMBL3342602 | — | — | 1 | 7.70 |
| CHEMBL3342609 | — | — | 1 | 7.66 |
| CHEMBL3342598 | — | — | 1 | 7.66 |
| CHEMBL3342599 | — | — | 1 | 7.62 |
| CHEMBL3342611 | — | — | 1 | 7.60 |
| CHEMBL3343184 | — | — | 1 | 7.60 |
| CHEMBL3342607 | — | — | 1 | 7.51 |
| CHEMBL3342614 | — | — | 1 | 7.50 |
| CHEMBL3342608 | — | — | 1 | 7.47 |
| CHEMBL3342606 | — | — | 1 | 7.47 |
| CHEMBL1337 | NITISINONE | 4.0 | 1 | 7.43 |
| CHEMBL3342601 | — | — | 1 | 7.42 |
| CHEMBL3343182 | — | — | 1 | 7.40 |
| CHEMBL3342600 | — | — | 1 | 7.24 |
| CHEMBL3343187 | — | — | 1 | 7.23 |
| CHEMBL3342612 | — | — | 1 | 7.22 |
| CHEMBL3342416 | — | — | 1 | 7.13 |
| CHEMBL3342415 | — | — | 1 | 7.10 |
| CHEMBL3342426 | — | — | 1 | 7.09 |
| CHEMBL3342412 | — | — | 1 | 7.07 |
| CHEMBL3342428 | — | — | 1 | 7.06 |
| CHEMBL3343186 | — | — | 1 | 7.05 |
| CHEMBL3342419 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342603 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3343183 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3342605 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3342604 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3342432 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3342610 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3342431 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3342602 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3342609 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3342598 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3342599 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3343184 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3342611 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3342607 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3342614 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL3342608 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL3342606 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL1337 | NITISINONE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3342601 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL3343182 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3342600 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL3343187 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL3342612 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3342416 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL3342415 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL3342426 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL3342412 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL3342428 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL3343186 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3342419 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3342418 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL3342430 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL3342422 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3342423 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL3342613 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3342425 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL3343185 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL3342417 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL3342429 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL3342414 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL3342427 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL3342421 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL3342424 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL3342420 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL3342413 | — | Ki | = | 248.0 | nM | 6.61 |