Assay Detail
Binding
CHEMBL3388873
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Inhibition of human recombinant MAOA expressed in Pichia pastoris incubated for 20 mins by bioluminescent-coupled assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.20 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330334 | — | — | 1 | 7.67 |
| CHEMBL3330339 | — | — | 1 | 7.16 |
| CHEMBL3330331 | — | — | 1 | 7.08 |
| CHEMBL3330341 | — | — | 1 | 7.03 |
| CHEMBL3330328 | — | — | 1 | 6.77 |
| CHEMBL3330337 | — | — | 1 | 6.63 |
| CHEMBL3330330 | — | — | 1 | 6.28 |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 5.92 |
| CHEMBL3330333 | — | — | 1 | 5.89 |
| CHEMBL3330335 | — | — | 1 | 5.89 |
| CHEMBL3330340 | — | — | 1 | 5.84 |
| CHEMBL3330329 | — | — | 1 | 5.72 |
| CHEMBL3330338 | — | — | 1 | 5.59 |
| CHEMBL3330332 | — | — | 1 | 5.46 |
| CHEMBL3330336 | — | — | 1 | 5.17 |
| CHEMBL3330342 | — | — | 1 | 5.08 |
| CHEMBL3330343 | — | — | 1 | - |
| CHEMBL3330344 | — | — | 1 | - |
| CHEMBL3330345 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330334 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL3330339 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3330331 | — | IC50 | = | 82.8 | nM | 7.08 |
| CHEMBL3330341 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3330328 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3330337 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL3330330 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3330333 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3330335 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3330340 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL3330329 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL3330338 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL3330332 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL3330336 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3330342 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL3330343 | — | IC50 | - | — | - | |
| CHEMBL3330344 | — | IC50 | - | — | - | |
| CHEMBL3330345 | — | IC50 | - | — | - |