Assay Detail
Binding
CHEMBL3388885
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Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate
35
Total Activities
35
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent 11β-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.64 | 8.30 |
| Inhibition | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3337694 | — | — | 1 | 8.30 |
| CHEMBL3337695 | — | — | 1 | 8.10 |
| CHEMBL3287169 | — | — | 1 | 7.22 |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 7.14 |
| CHEMBL3337676 | — | — | 1 | 7.07 |
| CHEMBL3337683 | — | — | 1 | 6.71 |
| CHEMBL3337679 | — | — | 1 | 6.69 |
| CHEMBL3337673 | — | — | 1 | 6.62 |
| CHEMBL3337664 | — | — | 1 | 6.60 |
| CHEMBL3337691 | — | — | 1 | 6.59 |
| CHEMBL3337684 | — | — | 1 | 6.58 |
| CHEMBL3337677 | — | — | 1 | 6.53 |
| CHEMBL3337666 | — | — | 1 | 6.50 |
| CHEMBL3337681 | — | — | 1 | 6.49 |
| CHEMBL3337685 | — | — | 1 | 6.46 |
| CHEMBL3337689 | — | — | 1 | 6.37 |
| CHEMBL3337686 | — | — | 1 | 6.33 |
| CHEMBL3337667 | — | — | 1 | 6.30 |
| CHEMBL3337678 | — | — | 1 | 6.29 |
| CHEMBL3337680 | — | — | 1 | 6.26 |
| CHEMBL3337690 | — | — | 1 | 6.25 |
| CHEMBL3337687 | — | — | 1 | 6.22 |
| CHEMBL3286405 | — | — | 1 | 6.22 |
| CHEMBL3337672 | — | — | 1 | 6.07 |
| CHEMBL3337665 | — | — | 1 | 6.07 |
| CHEMBL3337671 | — | — | 1 | - |
| CHEMBL3337670 | — | — | 1 | - |
| CHEMBL3337674 | — | — | 1 | - |
| CHEMBL3337688 | — | — | 1 | - |
| CHEMBL3337669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3337694 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3337695 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3287169 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL934 | METYRAPONE | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3337676 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3337683 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL3337679 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL3337673 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL3337664 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL3337691 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL3337684 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3337677 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL3337666 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3337681 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL3337685 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL3337689 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL3337686 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL3337667 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3337678 | — | IC50 | = | 519.0 | nM | 6.29 |
| CHEMBL3337680 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL3337690 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL3337687 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL3286405 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL3337672 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3337665 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3337668 | — | Inhibition | = | 34.0 | % | - |
| CHEMBL3337693 | — | Inhibition | = | 47.0 | % | - |
| CHEMBL3337692 | — | Inhibition | = | 28.0 | % | - |
| CHEMBL3337675 | — | Inhibition | = | 7.0 | % | - |
| CHEMBL3337682 | — | Inhibition | = | 47.0 | % | - |
| CHEMBL3337669 | — | Inhibition | = | 41.0 | % | - |
| CHEMBL3337688 | — | Inhibition | = | 22.0 | % | - |
| CHEMBL3337674 | — | Inhibition | = | 10.0 | % | - |
| CHEMBL3337670 | — | Inhibition | = | 8.0 | % | - |
| CHEMBL3337671 | — | Inhibition | = | 38.0 | % | - |