Assay Detail
Functional
CHEMBL3389012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of neurosphere formation of human BT142 cells by CCK8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT142 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.22 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343462 | — | — | 1 | 6.58 |
| CHEMBL2386126 | — | — | 1 | 6.43 |
| CHEMBL3343444 | — | — | 1 | 6.20 |
| CHEMBL3343463 | — | — | 1 | 6.16 |
| CHEMBL3343445 | — | — | 1 | 5.75 |
| CHEMBL2180727 | — | — | 1 | - |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343462 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2386126 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3343444 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3343463 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3343445 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2180727 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL810 | TEMOZOLOMIDE | EC50 | > | 50000.0 | nM | - |