Assay Detail
Functional
CHEMBL3389194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against HUVEC after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrids of phenylsulfonylfuroxan and coumarin as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.01 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358557 | — | — | 1 | 7.47 |
| CHEMBL3358561 | — | — | 1 | 7.01 |
| CHEMBL3358558 | — | — | 1 | 6.66 |
| CHEMBL3358560 | — | — | 1 | 6.60 |
| CHEMBL3359131 | — | — | 1 | 6.46 |
| CHEMBL3358556 | — | — | 1 | 6.43 |
| CHEMBL3358559 | — | — | 1 | 6.17 |
| CHEMBL3359126 | — | — | 1 | 6.05 |
| CHEMBL3359130 | — | — | 1 | 5.99 |
| CHEMBL3359125 | — | — | 1 | 5.52 |
| CHEMBL3359129 | — | — | 1 | 5.47 |
| CHEMBL299112 | — | — | 1 | 5.36 |
| CHEMBL455983 | — | — | 1 | 5.27 |
| CHEMBL3358554 | — | — | 1 | 5.26 |
| CHEMBL1946665 | — | — | 1 | 5.23 |
| CHEMBL3358553 | — | — | 1 | 5.17 |
| CHEMBL3358555 | — | — | 1 | - |
| CHEMBL3359127 | — | — | 1 | - |
| CHEMBL3359128 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358557 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3358561 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3358558 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3358560 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3359131 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3358556 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3358559 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL3359126 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3359130 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3359125 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL3359129 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL299112 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL455983 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL3358554 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL1946665 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL3358553 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL3358555 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3359127 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3359128 | — | IC50 | > | 20000.0 | nM | - |