Assay Detail
Binding
CHEMBL3389217
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Inhibition of human APE1 after 25 mins by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA repair nuclease/redox regulator APEX1 (CHEMBL5619) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.90 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109037 | — | — | 1 | 6.96 |
| CHEMBL1160025 | — | — | 1 | 6.60 |
| CHEMBL164 | MYRICETIN | — | 1 | 6.50 |
| CHEMBL1870764 | — | — | 1 | 5.52 |
| CHEMBL1524472 | — | — | 1 | 5.40 |
| CHEMBL279014 | LUCANTHONE | 2.0 | 1 | 5.30 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109037 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1160025 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL164 | MYRICETIN | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1870764 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1524472 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL279014 | LUCANTHONE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | IC50 | = | 10000.0 | nM | 5.00 |