Assay Detail
Binding
CHEMBL3389218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of APE1 (unknown origin) assessed as inhibition of redox activity
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA repair nuclease/redox regulator APEX1 (CHEMBL5619) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL578390 | APX-3330 | 2.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL578390 | APX-3330 | IC50 | = | 10000.0 | nM | 5.00 |