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Assay Detail

CHEMBL3389348

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds.
Leven M, Held J, Duffy S, Tschan S, Sax S, Kamber J, Frank W, Kuna K, Geffken D, Siethoff C, Barth S, Avery VM, Wittlin S, Mordmüller B, Kurz T.
J Med Chem (2014) 57 : 7971 -7976
PubMed 25195945 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 6.69 8.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL361497 ARTESUNATE 4.0 1 8.72
CHEMBL172 (S,R)-MEFLOQUINE 1 8.19
CHEMBL76 CHLOROQUINE 4.0 1 8.17
CHEMBL3335118 1 8.08
CHEMBL3335117 1 7.80
CHEMBL3335099 1 7.22
CHEMBL3335097 1 7.08
CHEMBL3335100 1 7.04
CHEMBL3335092 1 7.00
CHEMBL3335096 1 6.96
CHEMBL3335102 1 6.75
CHEMBL3335095 1 6.72
CHEMBL3335101 1 6.72
CHEMBL3335106 1 6.62
CHEMBL3335098 1 6.60
CHEMBL3335103 1 6.60
CHEMBL3335110 1 6.42
CHEMBL3335107 1 6.40
CHEMBL3335105 1 6.29
CHEMBL3335108 1 6.27
CHEMBL3335111 1 5.96
CHEMBL3335114 1 5.72
CHEMBL3335112 1 5.70
CHEMBL3335104 1 5.57
CHEMBL3335093 1 5.52
CHEMBL3335113 1 5.40
CHEMBL61 PODOFILOX 4.0 1 5.04
CHEMBL3335094 1 -
CHEMBL3335109 1 -
CHEMBL3335115 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL361497 ARTESUNATE IC50 = 1.9 nM 8.72
CHEMBL172 (S,R)-MEFLOQUINE IC50 = 6.5 nM 8.19
CHEMBL76 CHLOROQUINE IC50 = 6.8 nM 8.17
CHEMBL3335118 IC50 = 8.3 nM 8.08
CHEMBL3335117 IC50 = 16.0 nM 7.80
CHEMBL3335099 IC50 = 60.0 nM 7.22
CHEMBL3335097 IC50 = 83.0 nM 7.08
CHEMBL3335100 IC50 = 91.0 nM 7.04
CHEMBL3335092 IC50 = 100.0 nM 7.00
CHEMBL3335096 IC50 = 110.0 nM 6.96
CHEMBL3335102 IC50 = 180.0 nM 6.75
CHEMBL3335095 IC50 = 190.0 nM 6.72
CHEMBL3335101 IC50 = 190.0 nM 6.72
CHEMBL3335106 IC50 = 240.0 nM 6.62
CHEMBL3335098 IC50 = 250.0 nM 6.60
CHEMBL3335103 IC50 = 250.0 nM 6.60
CHEMBL3335110 IC50 = 380.0 nM 6.42
CHEMBL3335107 IC50 = 400.0 nM 6.40
CHEMBL3335105 IC50 = 510.0 nM 6.29
CHEMBL3335108 IC50 = 540.0 nM 6.27
CHEMBL3335111 IC50 = 1100.0 nM 5.96
CHEMBL3335114 IC50 = 1900.0 nM 5.72
CHEMBL3335112 IC50 = 2000.0 nM 5.70
CHEMBL3335104 IC50 = 2700.0 nM 5.57
CHEMBL3335093 IC50 = 3000.0 nM 5.52
CHEMBL3335113 IC50 = 4000.0 nM 5.40
CHEMBL61 PODOFILOX IC50 = 9200.0 nM 5.04
CHEMBL3335094 IC50 > 10000.0 nM -
CHEMBL3335109 IC50 > 10000.0 nM -
CHEMBL3335115 IC50 > 10000.0 nM -
CHEMBL3335116 IC50 > 10000.0 nM -