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Assay Detail

CHEMBL3389382

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Binding
Inhibition of integrin alphavbeta6 (unknown origin)-mediated K562 cell adhesion to LAPb1 coated surface by fluorescence analysis
ChEMBL ↗
39
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type K562
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Integrin alpha-V/beta-6 (CHEMBL2111416) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents.
Adams J, Anderson EC, Blackham EE, Chiu YW, Clarke T, Eccles N, Gill LA, Haye JJ, Haywood HT, Hoenig CR, Kausas M, Le J, Russell HL, Smedley C, Tipping WJ, Tongue T, Wood CC, Yeung J, Rowedder JE, Fray MJ, McInally T, Macdonald SJ.
ACS Med Chem Lett (2014) 5 : 1207 -1212
PubMed 25408832 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 6.38 7.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3356185 — — 3 7.20
CHEMBL3356174 — — 1 7.10
CHEMBL3356173 — — 1 7.00
CHEMBL3356154 — — 1 6.80
CHEMBL3356181 — — 1 6.80
CHEMBL3356179 — — 3 6.80
CHEMBL3356176 — — 1 6.70
CHEMBL3356178 — — 1 6.70
CHEMBL3356180 — — 1 6.70
CHEMBL267434 — — 1 6.70
CHEMBL3356184 — — 1 6.60
CHEMBL3356161 — — 1 6.60
CHEMBL3356172 — — 1 6.60
CHEMBL3356183 — — 1 6.50
CHEMBL3356163 — — 1 6.50
CHEMBL3356162 — — 1 6.40
CHEMBL3356171 — — 1 6.40
CHEMBL3356167 — — 1 6.40
CHEMBL3352854 — — 1 6.40
CHEMBL3356158 — — 1 6.40
CHEMBL3356166 — — 1 6.30
CHEMBL3356182 — — 1 6.30
CHEMBL3356164 — — 1 6.30
CHEMBL3356169 — — 1 6.20
CHEMBL3356170 — — 1 6.20
CHEMBL3356168 — — 1 6.20
CHEMBL3356160 — — 1 6.10
CHEMBL3356165 — — 1 6.10
CHEMBL3356156 — — 1 6.00
CHEMBL3356153 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3356185 — IC50 = 63.1 nM 7.20
CHEMBL3356174 — IC50 = 79.43 nM 7.10
CHEMBL3356173 — IC50 = 100.0 nM 7.00
CHEMBL3356185 — IC50 = 100.0 nM 7.00
CHEMBL3356154 — IC50 = 158.49 nM 6.80
CHEMBL3356181 — IC50 = 158.49 nM 6.80
CHEMBL3356179 — IC50 = 158.49 nM 6.80
CHEMBL267434 — IC50 = 199.53 nM 6.70
CHEMBL3356176 — IC50 = 199.53 nM 6.70
CHEMBL3356178 — IC50 = 199.53 nM 6.70
CHEMBL3356180 — IC50 = 199.53 nM 6.70
CHEMBL3356179 — IC50 = 251.19 nM 6.60
CHEMBL3356172 — IC50 = 251.19 nM 6.60
CHEMBL3356161 — IC50 = 251.19 nM 6.60
CHEMBL3356184 — IC50 = 251.19 nM 6.60
CHEMBL3356183 — IC50 = 316.23 nM 6.50
CHEMBL3356163 — IC50 = 316.23 nM 6.50
CHEMBL3356171 — IC50 = 398.11 nM 6.40
CHEMBL3352854 — IC50 = 398.11 nM 6.40
CHEMBL3356162 — IC50 = 398.11 nM 6.40
CHEMBL3356167 — IC50 = 398.11 nM 6.40
CHEMBL3356158 — IC50 = 398.11 nM 6.40
CHEMBL3356166 — IC50 = 501.19 nM 6.30
CHEMBL3356164 — IC50 = 501.19 nM 6.30
CHEMBL3356182 — IC50 = 501.19 nM 6.30
CHEMBL3356168 — IC50 = 630.96 nM 6.20
CHEMBL3356169 — IC50 = 630.96 nM 6.20
CHEMBL3356170 — IC50 = 630.96 nM 6.20
CHEMBL3356160 — IC50 = 794.33 nM 6.10
CHEMBL3356165 — IC50 = 794.33 nM 6.10
CHEMBL3356153 — IC50 = 1000.0 nM 6.00
CHEMBL3356156 — IC50 = 1000.0 nM 6.00
CHEMBL3356155 — IC50 = 1995.26 nM 5.70
CHEMBL3356179 — IC50 = 6309.57 nM 5.20
CHEMBL3356175 — IC50 = 6309.57 nM 5.20
CHEMBL3356177 — IC50 = 7943.28 nM 5.10
CHEMBL3356157 — IC50 > 10000.0 nM -
CHEMBL3356159 — IC50 > 10000.0 nM -
CHEMBL3356185 — IC50 > 10000.0 nM -