Assay Detail
Binding
CHEMBL3389383
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of integrin alphavbeta3 (unknown origin)-mediated K562 cell adhesion to LAPb1 coated surface by fluorescence analysis
37
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.85 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356184 | — | — | 1 | 7.80 |
| CHEMBL3356154 | — | — | 1 | 7.60 |
| CHEMBL3356166 | — | — | 1 | 7.60 |
| CHEMBL3356160 | — | — | 1 | 7.50 |
| CHEMBL3356163 | — | — | 1 | 7.40 |
| CHEMBL3356165 | — | — | 1 | 7.40 |
| CHEMBL3356158 | — | — | 1 | 7.30 |
| CHEMBL3356178 | — | — | 1 | 7.30 |
| CHEMBL3356180 | — | — | 1 | 7.20 |
| CHEMBL3356161 | — | — | 1 | 7.10 |
| CHEMBL3356167 | — | — | 1 | 7.10 |
| CHEMBL3356183 | — | — | 1 | 7.00 |
| CHEMBL3356171 | — | — | 1 | 7.00 |
| CHEMBL3356174 | — | — | 1 | 7.00 |
| CHEMBL3356155 | — | — | 1 | 7.00 |
| CHEMBL3356164 | — | — | 1 | 7.00 |
| CHEMBL3356181 | — | — | 1 | 6.90 |
| CHEMBL3352854 | — | — | 1 | 6.90 |
| CHEMBL3356170 | — | — | 1 | 6.90 |
| CHEMBL3356179 | — | — | 3 | 6.90 |
| CHEMBL3356162 | — | — | 1 | 6.80 |
| CHEMBL3356185 | — | — | 3 | 6.80 |
| CHEMBL3356169 | — | — | 1 | 6.80 |
| CHEMBL3356172 | — | — | 1 | 6.70 |
| CHEMBL3356173 | — | — | 1 | 6.70 |
| CHEMBL3356168 | — | — | 1 | 6.60 |
| CHEMBL3356156 | — | — | 1 | 6.50 |
| CHEMBL3356176 | — | — | 1 | 6.40 |
| CHEMBL3356182 | — | — | 1 | 6.40 |
| CHEMBL3356159 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356184 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3356166 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3356154 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3356160 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3356163 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3356165 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3356178 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3356158 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3356180 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL3356161 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3356167 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3356155 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3356164 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3356174 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3356171 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3356183 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3356170 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3356181 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3356179 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3352854 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3356162 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL3356169 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL3356185 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL3356172 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL3356173 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL3356168 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL3356185 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3356156 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3356176 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3356179 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3356182 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3356159 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3356185 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3356157 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL3356177 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3356175 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3356179 | — | IC50 | > | 10000.0 | nM | - |