Assay Detail
Binding
CHEMBL3389427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovine COX2 assessed as reduction in PGF2alpha formation incubated for 18 hrs by enzyme immunoassay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.72 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.82 |
| CHEMBL3331326 | — | — | 1 | 5.75 |
| CHEMBL3331330 | — | — | 1 | 5.63 |
| CHEMBL103836 | — | — | 1 | 5.61 |
| CHEMBL3331339 | — | — | 1 | 5.59 |
| CHEMBL412610 | — | — | 1 | 5.58 |
| CHEMBL2402696 | — | — | 1 | 5.44 |
| CHEMBL3331333 | — | — | 1 | 5.36 |
| CHEMBL3331327 | — | — | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL3331341 | — | — | 1 | - |
| CHEMBL3331340 | — | — | 1 | - |
| CHEMBL3331328 | — | — | 1 | - |
| CHEMBL3331338 | — | — | 1 | - |
| CHEMBL3331337 | — | — | 1 | - |
| CHEMBL3331336 | — | — | 1 | - |
| CHEMBL3331335 | — | — | 1 | - |
| CHEMBL3331334 | — | — | 1 | - |
| CHEMBL3331332 | — | — | 1 | - |
| CHEMBL3331331 | — | — | 1 | - |
| CHEMBL3331329 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3331326 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL3331330 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL103836 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL3331339 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL412610 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL2402696 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL3331333 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL3331327 | — | IC50 | - | — | - | |
| CHEMBL6 | INDOMETHACIN | IC50 | - | — | - | |
| CHEMBL3331341 | — | IC50 | - | — | - | |
| CHEMBL3331340 | — | IC50 | - | — | - | |
| CHEMBL3331328 | — | IC50 | - | — | - | |
| CHEMBL3331338 | — | IC50 | - | — | - | |
| CHEMBL3331337 | — | IC50 | - | — | - | |
| CHEMBL3331336 | — | IC50 | - | — | - | |
| CHEMBL3331335 | — | IC50 | - | — | - | |
| CHEMBL3331334 | — | IC50 | - | — | - | |
| CHEMBL3331332 | — | IC50 | - | — | - | |
| CHEMBL3331331 | — | IC50 | - | — | - | |
| CHEMBL3331329 | — | IC50 | - | — | - |