Assay Detail
ADMET
CHEMBL3389577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MDR1 (unknown origin) expressed in MDA T0.3 cells using rhodamine 123 substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MDA T0.3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.72 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651956 | ALISPORIVIR | 3.0 | 1 | 6.23 |
| CHEMBL3344501 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651956 | ALISPORIVIR | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3344501 | — | IC50 | = | 6300.0 | nM | 5.20 |