Assay Detail
Binding
CHEMBL3389583
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Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.57 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3354136 | — | — | 1 | 8.43 |
| CHEMBL3354132 | — | — | 1 | 8.42 |
| CHEMBL3354134 | — | — | 1 | 8.38 |
| CHEMBL3354133 | — | — | 1 | 8.28 |
| CHEMBL3354135 | — | — | 1 | 8.24 |
| CHEMBL3354131 | — | — | 1 | 8.19 |
| CHEMBL78755 | — | — | 1 | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL3354129 | — | — | 1 | 7.72 |
| CHEMBL3099282 | — | — | 1 | 7.68 |
| CHEMBL3354126 | — | — | 1 | 7.47 |
| CHEMBL3354128 | — | — | 1 | 7.46 |
| CHEMBL3354130 | — | — | 1 | 7.42 |
| CHEMBL3354127 | — | — | 1 | 7.39 |
| CHEMBL3354139 | — | — | 1 | 5.13 |
| CHEMBL3354140 | — | — | 1 | 5.09 |
| CHEMBL3354137 | — | — | 1 | - |
| CHEMBL3354138 | — | — | 1 | - |
| CHEMBL3354141 | — | — | 1 | - |
| CHEMBL3354142 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3354136 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL3354132 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL3354134 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL3354133 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL3354135 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL3354131 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL78755 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3354129 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL3099282 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3354126 | — | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL3354128 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL3354130 | — | Ki | = | 37.6 | nM | 7.42 |
| CHEMBL3354127 | — | Ki | = | 40.3 | nM | 7.39 |
| CHEMBL3354139 | — | Ki | = | 7380.0 | nM | 5.13 |
| CHEMBL3354140 | — | Ki | = | 8160.0 | nM | 5.09 |
| CHEMBL3354137 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3354138 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3354141 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3354142 | — | Ki | > | 10000.0 | nM | - |