Assay Detail
Binding
CHEMBL3389584
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Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.69 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78755 | — | — | 1 | 8.89 |
| CHEMBL3354133 | — | — | 1 | 8.09 |
| CHEMBL3354128 | — | — | 1 | 8.05 |
| CHEMBL3354132 | — | — | 1 | 8.04 |
| CHEMBL3354127 | — | — | 1 | 8.02 |
| CHEMBL3354131 | — | — | 1 | 8.02 |
| CHEMBL3099282 | — | — | 1 | 8.01 |
| CHEMBL3354130 | — | — | 1 | 8.01 |
| CHEMBL3354134 | — | — | 1 | 8.01 |
| CHEMBL3354140 | — | — | 1 | 7.70 |
| CHEMBL3354138 | — | — | 1 | 7.64 |
| CHEMBL3354141 | — | — | 1 | 7.64 |
| CHEMBL3354129 | — | — | 1 | 7.61 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL3354135 | — | — | 1 | 7.17 |
| CHEMBL3354126 | — | — | 1 | 7.13 |
| CHEMBL3354136 | — | — | 1 | 7.10 |
| CHEMBL3354142 | — | — | 1 | 7.06 |
| CHEMBL3354139 | — | — | 1 | 7.05 |
| CHEMBL3354137 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78755 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL3354133 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL3354128 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL3354132 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3354127 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL3354131 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL3099282 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL3354130 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL3354134 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL3354140 | — | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL3354138 | — | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL3354141 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL3354129 | — | Ki | = | 24.3 | nM | 7.61 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3354135 | — | Ki | = | 68.4 | nM | 7.17 |
| CHEMBL3354126 | — | Ki | = | 74.6 | nM | 7.13 |
| CHEMBL3354136 | — | Ki | = | 78.9 | nM | 7.10 |
| CHEMBL3354142 | — | Ki | = | 87.8 | nM | 7.06 |
| CHEMBL3354139 | — | Ki | = | 89.2 | nM | 7.05 |
| CHEMBL3354137 | — | Ki | = | 90.7 | nM | 7.04 |