Assay Detail
Binding
CHEMBL3389585
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Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.26 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3354129 | — | — | 1 | 9.17 |
| CHEMBL3354128 | — | — | 1 | 9.10 |
| CHEMBL78755 | — | — | 1 | 8.82 |
| CHEMBL3354126 | — | — | 1 | 8.39 |
| CHEMBL3354130 | — | — | 1 | 8.34 |
| CHEMBL3354136 | — | — | 1 | 8.29 |
| CHEMBL3354134 | — | — | 1 | 8.25 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL3354131 | — | — | 1 | 8.23 |
| CHEMBL3354132 | — | — | 1 | 8.22 |
| CHEMBL3354140 | — | — | 1 | 8.22 |
| CHEMBL3354133 | — | — | 1 | 8.19 |
| CHEMBL3354135 | — | — | 1 | 8.17 |
| CHEMBL3099282 | — | — | 1 | 8.17 |
| CHEMBL3354142 | — | — | 1 | 8.12 |
| CHEMBL3354141 | — | — | 1 | 8.11 |
| CHEMBL3354139 | — | — | 1 | 8.05 |
| CHEMBL3354138 | — | — | 1 | 8.03 |
| CHEMBL3354127 | — | — | 1 | 8.02 |
| CHEMBL3354137 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3354129 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL3354128 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL78755 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3354126 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL3354130 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL3354136 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL3354134 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL3354131 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL3354132 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3354140 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3354133 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL3354135 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL3099282 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL3354142 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL3354141 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL3354139 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL3354138 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL3354127 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL3354137 | — | Ki | = | 68.5 | nM | 7.16 |