Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3389701

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Dengue virus serotype 2 NS2B-NS3 protease by homogeneous fluorimetric assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism dengue virus type 2
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Genome polyprotein (CHEMBL3308998)
Type SINGLE PROTEIN
Organism dengue virus type 2

Publication

C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease.
Behnam MA, Nitsche C, Vechi SM, Klein CD.
ACS Med Chem Lett (2014) 5 : 1037 -1042
PubMed 25221663 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 4.75 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3335518 1 6.22
CHEMBL3335517 1 5.89
CHEMBL2440353 1 5.60
CHEMBL3335494 1 5.48
CHEMBL2440341 1 5.28
CHEMBL3335499 1 5.13
CHEMBL3335511 1 5.09
CHEMBL3335520 1 4.98
CHEMBL3335488 1 4.92
CHEMBL2440339 1 4.88
CHEMBL3335496 1 4.85
CHEMBL3335510 1 4.84
CHEMBL3335497 1 4.80
CHEMBL3335509 1 4.76
CHEMBL3335505 1 4.76
CHEMBL3335512 1 4.76
CHEMBL3335498 1 4.75
CHEMBL3335490 1 4.68
CHEMBL3335513 1 4.64
CHEMBL3335492 1 4.60
CHEMBL3335519 1 4.60
CHEMBL3335514 1 4.55
CHEMBL3335516 1 4.54
CHEMBL3335522 1 4.53
CHEMBL3335487 1 4.52
CHEMBL3335507 1 4.52
CHEMBL3335489 1 4.45
CHEMBL3335508 1 4.35
CHEMBL3335501 1 4.33
CHEMBL3335491 1 4.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3335518 IC50 = 600.0 nM 6.22
CHEMBL3335517 IC50 = 1300.0 nM 5.89
CHEMBL2440353 IC50 = 2500.0 nM 5.60
CHEMBL3335494 IC50 = 3300.0 nM 5.48
CHEMBL2440341 IC50 = 5300.0 nM 5.28
CHEMBL3335499 IC50 = 7400.0 nM 5.13
CHEMBL3335511 IC50 = 8200.0 nM 5.09
CHEMBL3335520 IC50 = 10500.0 nM 4.98
CHEMBL3335488 IC50 = 11900.0 nM 4.92
CHEMBL2440339 IC50 = 13300.0 nM 4.88
CHEMBL3335496 IC50 = 14100.0 nM 4.85
CHEMBL3335510 IC50 = 14400.0 nM 4.84
CHEMBL3335497 IC50 = 15800.0 nM 4.80
CHEMBL3335512 IC50 = 17400.0 nM 4.76
CHEMBL3335505 IC50 = 17500.0 nM 4.76
CHEMBL3335509 IC50 = 17500.0 nM 4.76
CHEMBL3335498 IC50 = 17600.0 nM 4.75
CHEMBL3335490 IC50 = 21000.0 nM 4.68
CHEMBL3335513 IC50 = 22700.0 nM 4.64
CHEMBL3335492 IC50 = 25200.0 nM 4.60
CHEMBL3335519 IC50 = 24900.0 nM 4.60
CHEMBL3335514 IC50 = 28200.0 nM 4.55
CHEMBL3335516 IC50 = 28800.0 nM 4.54
CHEMBL3335522 IC50 = 29800.0 nM 4.53
CHEMBL3335487 IC50 = 30100.0 nM 4.52
CHEMBL3335507 IC50 = 30100.0 nM 4.52
CHEMBL3335489 IC50 = 35600.0 nM 4.45
CHEMBL3335508 IC50 = 44300.0 nM 4.35
CHEMBL3335501 IC50 = 46700.0 nM 4.33
CHEMBL3335491 IC50 = 47500.0 nM 4.32
CHEMBL3335521 IC50 = 57600.0 nM 4.24
CHEMBL3335495 IC50 = 65800.0 nM 4.18
CHEMBL3335504 IC50 = 92200.0 nM 4.04
CHEMBL3335503 IC50 = 96600.0 nM 4.01
CHEMBL3335515 IC50 = 98600.0 nM 4.01
CHEMBL3335502 IC50 = 191900.0 nM -
CHEMBL3335506 IC50 = 159200.0 nM -
CHEMBL3335500 IC50 = 109300.0 nM -
CHEMBL3335493 IC50 = 137200.0 nM -