Assay Detail
Functional
CHEMBL3389720
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Cytotoxic activity against human A549 cells after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 21-alkynylaryl pregnenolone derivatives and evaluation of their anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.62 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3357749 | — | — | 1 | 5.20 |
| CHEMBL3352870 | — | — | 1 | 4.70 |
| CHEMBL3357750 | — | — | 1 | 4.68 |
| CHEMBL3357745 | — | — | 1 | 4.60 |
| CHEMBL3357746 | — | — | 1 | 4.55 |
| CHEMBL3357748 | — | — | 1 | 4.52 |
| CHEMBL3357751 | — | — | 1 | 4.39 |
| CHEMBL90593 | PRASTERONE | 4.0 | 1 | 4.32 |
| CHEMBL3357747 | — | — | 1 | - |
| CHEMBL3357752 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3357749 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3352870 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL3357750 | — | IC50 | = | 20740.0 | nM | 4.68 |
| CHEMBL3357745 | — | IC50 | = | 24950.0 | nM | 4.60 |
| CHEMBL3357746 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL3357748 | — | IC50 | = | 30470.0 | nM | 4.52 |
| CHEMBL3357751 | — | IC50 | = | 40570.0 | nM | 4.39 |
| CHEMBL90593 | PRASTERONE | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL3357747 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3357752 | — | IC50 | > | 50000.0 | nM | - |