Assay Detail
Binding
CHEMBL3390067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (CHEMBL3964) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.20 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355737 | — | — | 1 | 6.75 |
| CHEMBL3355726 | — | — | 1 | 6.27 |
| CHEMBL3355311 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355737 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3355726 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3355311 | — | IC50 | = | 2600.0 | nM | 5.58 |