Assay Detail
Binding
CHEMBL3390165
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARgamma expressed in HEK293 cells incubated for 18 hrs by luciferase reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.88 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.68 |
| CHEMBL3358034 | — | — | 1 | 5.77 |
| CHEMBL3358037 | — | — | 1 | 5.77 |
| CHEMBL3358033 | — | — | 1 | 5.72 |
| CHEMBL3358035 | — | — | 1 | 5.70 |
| CHEMBL3358036 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3358034 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3358037 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3358033 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3358035 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3358036 | — | EC50 | = | 2300.0 | nM | 5.64 |