Assay Detail
Functional
CHEMBL3390205
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of the antiplasmodial activity of novel indeno[2,1-c]quinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.08 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.92 |
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 7.92 |
| CHEMBL3344524 | — | — | 1 | 6.28 |
| CHEMBL3344526 | — | — | 1 | 6.09 |
| CHEMBL3344523 | — | — | 1 | 6.07 |
| CHEMBL3344519 | — | — | 1 | 5.99 |
| CHEMBL3344516 | — | — | 1 | 5.77 |
| CHEMBL3344517 | — | — | 1 | 5.63 |
| CHEMBL3344525 | — | — | 1 | 5.27 |
| CHEMBL3344518 | — | — | 1 | 5.17 |
| CHEMBL216579 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3344524 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3344526 | — | IC50 | = | 818.0 | nM | 6.09 |
| CHEMBL3344523 | — | IC50 | = | 843.0 | nM | 6.07 |
| CHEMBL3344519 | — | IC50 | = | 1031.0 | nM | 5.99 |
| CHEMBL3344516 | — | IC50 | = | 1713.0 | nM | 5.77 |
| CHEMBL3344517 | — | IC50 | = | 2339.0 | nM | 5.63 |
| CHEMBL3344525 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL3344518 | — | IC50 | = | 6775.0 | nM | 5.17 |
| CHEMBL216579 | — | IC50 | = | 16900.0 | nM | 4.77 |