Assay Detail
Binding
CHEMBL3390209
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Inhibition of Influenza A virus A/duck/china/1206/2012(H5N1) Neuraminidase
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL3559643) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/USSR/90/1977 H1N1) |
Publication
Discovery of N-substituted oseltamivir derivatives as potent and selective inhibitors of H5N1 influenza neuraminidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.02 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81717 | — | — | 1 | 8.64 |
| CHEMBL3342478 | — | — | 1 | 8.42 |
| CHEMBL3342485 | — | — | 1 | 8.37 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.89 |
| CHEMBL3342474 | — | — | 1 | 7.85 |
| CHEMBL3342471 | — | — | 1 | 7.72 |
| CHEMBL3342483 | — | — | 1 | 7.57 |
| CHEMBL3342475 | — | — | 1 | 7.42 |
| CHEMBL3342484 | — | — | 1 | 7.41 |
| CHEMBL3342467 | — | — | 1 | 7.37 |
| CHEMBL3342477 | — | — | 1 | 7.32 |
| CHEMBL3342470 | — | — | 1 | 7.28 |
| CHEMBL3342468 | — | — | 1 | 7.25 |
| CHEMBL3342473 | — | — | 1 | 7.20 |
| CHEMBL3342479 | — | — | 1 | 7.09 |
| CHEMBL3342469 | — | — | 1 | 7.08 |
| CHEMBL3342456 | — | — | 1 | 7.06 |
| CHEMBL3342476 | — | — | 1 | 7.05 |
| CHEMBL3342472 | — | — | 1 | 6.93 |
| CHEMBL3342458 | — | — | 1 | 6.60 |
| CHEMBL3342459 | — | — | 1 | 6.57 |
| CHEMBL3342461 | — | — | 1 | 6.41 |
| CHEMBL3342460 | — | — | 1 | 5.94 |
| CHEMBL3342457 | — | — | 1 | 5.81 |
| CHEMBL3342466 | — | — | 1 | 5.75 |
| CHEMBL3342464 | — | — | 1 | 5.59 |
| CHEMBL3341765 | — | — | 1 | 5.52 |
| CHEMBL3342462 | — | — | 1 | 5.44 |
| CHEMBL3342331 | — | — | 1 | - |
| CHEMBL3342482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81717 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3342478 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3342485 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3342474 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3342471 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3342483 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3342475 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3342484 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3342467 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3342477 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3342470 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3342468 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3342473 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3342479 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3342469 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3342456 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3342476 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3342472 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3342458 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3342459 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3342461 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3342460 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL3342457 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL3342466 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL3342464 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL3341765 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL3342462 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL3342331 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3342482 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3342481 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3342480 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3342330 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3342463 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3342465 | — | IC50 | > | 3000.0 | nM | - |