Assay Detail
Binding
CHEMBL3390449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins by spectrophotometric method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.71 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343927 | — | — | 1 | 7.67 |
| CHEMBL3343922 | — | — | 1 | 7.49 |
| CHEMBL3343885 | — | — | 1 | 7.39 |
| CHEMBL3343931 | — | — | 1 | 7.29 |
| CHEMBL3343882 | — | — | 1 | 7.29 |
| CHEMBL3343930 | — | — | 1 | 7.17 |
| CHEMBL3343925 | — | — | 1 | 7.01 |
| CHEMBL3343920 | — | — | 1 | 6.97 |
| CHEMBL3343932 | — | — | 1 | 6.94 |
| CHEMBL3343923 | — | — | 1 | 6.90 |
| CHEMBL3343926 | — | — | 1 | 6.85 |
| CHEMBL3343929 | — | — | 1 | 6.81 |
| CHEMBL3343924 | — | — | 1 | 6.64 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.58 |
| CHEMBL3343884 | — | — | 1 | 6.57 |
| CHEMBL3343928 | — | — | 1 | 6.41 |
| CHEMBL3343883 | — | — | 1 | 6.31 |
| CHEMBL3343921 | — | — | 1 | 6.11 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.57 |
| CHEMBL453066 | BETA-CCM | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343927 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL3343922 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL3343885 | — | IC50 | = | 40.6 | nM | 7.39 |
| CHEMBL3343931 | — | IC50 | = | 51.6 | nM | 7.29 |
| CHEMBL3343882 | — | IC50 | = | 51.7 | nM | 7.29 |
| CHEMBL3343930 | — | IC50 | = | 67.3 | nM | 7.17 |
| CHEMBL3343925 | — | IC50 | = | 97.7 | nM | 7.01 |
| CHEMBL3343920 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3343932 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL3343923 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL3343926 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3343929 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL3343924 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL95 | TACRINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3343884 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL3343928 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL3343883 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL3343921 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL453066 | BETA-CCM | IC50 | = | 63000.0 | nM | 4.20 |