Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3390778

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Signal transducer and activator of transcription 5B (CHEMBL5817)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein.
Cumaraswamy AA, Lewis AM, Geletu M, Todic A, Diaz DB, Cheng XR, Brown CE, Laister RC, Muench D, Kerman K, Grimes HL, Minden MD, Gunning PT.
ACS Med Chem Lett (2014) 5 : 1202 -1206
PubMed 25419444 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 5.44 6.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3358611 1 6.84
CHEMBL3358598 1 5.32
CHEMBL3358596 1 5.18
CHEMBL3358610 1 4.94
CHEMBL3358608 1 4.91
CHEMBL3358609 1 -
CHEMBL3358607 1 -
CHEMBL3358606 1 -
CHEMBL3358605 1 -
CHEMBL3358604 1 -
CHEMBL3358603 1 -
CHEMBL3358602 1 -
CHEMBL3358601 1 -
CHEMBL3358600 1 -
CHEMBL3358599 1 -
CHEMBL3358597 1 -
CHEMBL3358595 1 -
CHEMBL3358594 1 -
CHEMBL3358593 1 -
CHEMBL3358592 1 -
CHEMBL3358591 1 -
CHEMBL3358590 1 -
CHEMBL3358589 1 -
CHEMBL3358588 1 -
CHEMBL3358587 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3358611 Ki = 145.8 nM 6.84
CHEMBL3358598 Ki = 4770.0 nM 5.32
CHEMBL3358596 Ki = 6620.0 nM 5.18
CHEMBL3358610 Ki = 11500.0 nM 4.94
CHEMBL3358608 Ki = 12360.0 nM 4.91
CHEMBL3358609 Ki > 60000.0 nM -
CHEMBL3358607 Ki > 60000.0 nM -
CHEMBL3358606 Ki > 60000.0 nM -
CHEMBL3358605 Ki > 60000.0 nM -
CHEMBL3358604 Ki > 60000.0 nM -
CHEMBL3358603 Ki > 60000.0 nM -
CHEMBL3358602 Ki > 60000.0 nM -
CHEMBL3358601 Ki > 60000.0 nM -
CHEMBL3358600 Ki > 60000.0 nM -
CHEMBL3358599 Ki > 60000.0 nM -
CHEMBL3358597 Ki > 60000.0 nM -
CHEMBL3358595 Ki > 60000.0 nM -
CHEMBL3358594 Ki > 60000.0 nM -
CHEMBL3358593 Ki > 60000.0 nM -
CHEMBL3358592 Ki > 60000.0 nM -
CHEMBL3358591 Ki > 60000.0 nM -
CHEMBL3358590 Ki > 60000.0 nM -
CHEMBL3358589 Ki > 60000.0 nM -
CHEMBL3358588 Ki > 60000.0 nM -
CHEMBL3358587 Ki > 60000.0 nM -