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Assay Detail

CHEMBL3390785

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and evaluation of the antiplasmodial activity of novel indeno[2,1-c]quinoline derivatives.
Barteselli A, Parapini S, Basilico N, Mommo D, Sparatore A.
Bioorg Med Chem (2014) 22 : 5757 -5765
PubMed 25311562 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.06 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL38827 LUMEFANTRINE 4.0 1 7.92
CHEMBL3344524 1 6.61
CHEMBL3344523 1 6.59
CHEMBL76 CHLOROQUINE 4.0 1 6.50
CHEMBL3344531 1 6.37
CHEMBL3344520 1 6.27
CHEMBL3344519 1 6.25
CHEMBL3344516 1 6.20
CHEMBL3344526 1 6.16
CHEMBL3344527 1 5.98
CHEMBL3344517 1 5.93
CHEMBL3344521 1 5.93
CHEMBL3344518 1 5.59
CHEMBL3344525 1 5.56
CHEMBL3344532 1 5.50
CHEMBL3344529 1 5.38
CHEMBL3344528 1 5.17
CHEMBL3344522 1 5.16
CHEMBL3344530 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL38827 LUMEFANTRINE IC50 = 12.0 nM 7.92
CHEMBL3344524 IC50 = 244.0 nM 6.61
CHEMBL3344523 IC50 = 255.0 nM 6.59
CHEMBL76 CHLOROQUINE IC50 = 316.0 nM 6.50
CHEMBL3344531 IC50 = 432.0 nM 6.37
CHEMBL3344520 IC50 = 534.0 nM 6.27
CHEMBL3344519 IC50 = 568.0 nM 6.25
CHEMBL3344516 IC50 = 626.0 nM 6.20
CHEMBL3344526 IC50 = 699.0 nM 6.16
CHEMBL3344527 IC50 = 1055.0 nM 5.98
CHEMBL3344517 IC50 = 1172.0 nM 5.93
CHEMBL3344521 IC50 = 1186.0 nM 5.93
CHEMBL3344518 IC50 = 2554.0 nM 5.59
CHEMBL3344525 IC50 = 2728.0 nM 5.56
CHEMBL3344532 IC50 = 3157.0 nM 5.50
CHEMBL3344529 IC50 = 4160.0 nM 5.38
CHEMBL3344528 IC50 = 6807.0 nM 5.17
CHEMBL3344522 IC50 = 6936.0 nM 5.16
CHEMBL3344530 IC50 > 5000.0 nM -