Assay Detail
Binding
CHEMBL3390812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HMG-CoA reductase activity using NADPH by spectrophotometrically
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and highly potent hypolipidemic activity of alpha-asarone- and fibrate-based 2-acyl and 2-alkyl phenols as HMG-CoA reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.25 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163691 | — | — | 1 | 5.32 |
| CHEMBL3344536 | — | — | 1 | 5.31 |
| CHEMBL333306 | TRANS-ASARONE | — | 1 | 5.23 |
| CHEMBL1163189 | — | — | 1 | 5.21 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 5.21 |
| CHEMBL3344540 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163691 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL3344536 | — | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL333306 | TRANS-ASARONE | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL1163189 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL3344540 | — | IC50 | = | 6430.0 | nM | 5.19 |