Assay Detail
Binding
CHEMBL3390925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-6-tagged human JMJD2E (1 to 337 residues) expressed in Escherichia coli using ARK(me3)STGGK peptide as substrate by MALDI-TOF/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of second generation epigenetic agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.83 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230640 | — | — | 1 | 6.70 |
| CHEMBL1486366 | — | — | 1 | 5.96 |
| CHEMBL1435274 | — | — | 1 | 5.70 |
| CHEMBL1519338 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230640 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1486366 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1435274 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1519338 | — | IC50 | = | 11000.0 | nM | 4.96 |