Assay Detail
Binding
CHEMBL3391341
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Inhibition of LIMK2 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.79 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2141887 | — | — | 1 | 7.07 |
| CHEMBL3347507 | — | — | 1 | 7.05 |
| CHEMBL3347669 | — | — | 1 | 6.99 |
| CHEMBL3347513 | — | — | 1 | 6.88 |
| CHEMBL3347683 | — | — | 1 | 6.80 |
| CHEMBL3347528 | — | — | 1 | 6.79 |
| CHEMBL3347689 | — | — | 1 | 6.56 |
| CHEMBL2070615 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2141887 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3347507 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3347669 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL3347513 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL3347683 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL3347528 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3347689 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL2070615 | — | IC50 | = | 696.0 | nM | 6.16 |