Assay Detail
Binding
CHEMBL3391379
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Inhibition of SIRT-1 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of second generation epigenetic agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.69 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561194 | ANILINOBENZAMIDE | — | 1 | 4.77 |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561194 | ANILINOBENZAMIDE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 25000.0 | nM | 4.60 |