Assay Detail
Functional
CHEMBL3391645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound-healing assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mannich- and LedererManasse-based analogues of the natural product S-(+)-curcuphenol as cancer proliferation and migration inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.93 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3347458 | — | — | 1 | 5.51 |
| CHEMBL3347392 | — | — | 1 | 5.09 |
| CHEMBL1630455 | — | — | 1 | 5.02 |
| CHEMBL1630456 | — | — | 1 | 5.00 |
| CHEMBL3347472 | — | — | 1 | 4.96 |
| CHEMBL3347471 | — | — | 1 | 4.91 |
| CHEMBL3347445 | — | — | 1 | 4.52 |
| CHEMBL451860 | — | — | 1 | 4.43 |
| CHEMBL3347459 | — | — | 1 | - |
| CHEMBL3347457 | — | — | 1 | - |
| CHEMBL3347444 | — | — | 1 | - |
| CHEMBL3347391 | — | — | 1 | - |
| CHEMBL3347470 | — | — | 1 | - |
| CHEMBL3347473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3347458 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3347392 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1630455 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1630456 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3347472 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL3347471 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL3347445 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL451860 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL3347459 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3347457 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3347444 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3347391 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3347470 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3347473 | — | IC50 | > | 20000.0 | nM | - |