Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3392923

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2.
ChEMBL ↗
315
Total Activities
315
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

MMV box screening in the Dd2 P. falciparum strain
Horrocks lab, Keele University, UK.

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 315 6.06 7.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL317364 — — 1 7.36
CHEMBL584237 — — 1 7.08
CHEMBL598279 — — 1 7.04
CHEMBL533017 — — 1 6.98
CHEMBL532987 — — 1 6.92
CHEMBL535079 — — 1 6.90
CHEMBL601156 — — 1 6.89
CHEMBL2028042 — — 1 6.86
CHEMBL535730 — — 1 6.85
CHEMBL590435 — — 1 6.81
CHEMBL475813 — — 1 6.81
CHEMBL530223 — — 1 6.80
CHEMBL597262 — — 1 6.80
CHEMBL586704 — — 1 6.80
CHEMBL533563 — — 1 6.75
CHEMBL532079 — — 1 6.74
CHEMBL548469 — — 1 6.71
CHEMBL592550 — — 1 6.71
CHEMBL261095 — — 1 6.70
CHEMBL585622 — — 1 6.70
CHEMBL547476 — — 1 6.68
CHEMBL592105 METHYLROSANILINE -1.0 1 6.66
CHEMBL124006 — — 1 6.63
CHEMBL1545915 — — 1 6.62
CHEMBL532879 — — 1 6.62
CHEMBL588855 — — 1 6.62
CHEMBL2028057 — — 1 6.58
CHEMBL546799 — — 1 6.58
CHEMBL547443 — — 1 6.57
CHEMBL546162 — — 1 6.56

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL317364 — IC50 = 44.01 nM 7.36
CHEMBL584237 — IC50 = 82.67 nM 7.08
CHEMBL598279 — IC50 = 90.59 nM 7.04
CHEMBL533017 — IC50 = 104.2 nM 6.98
CHEMBL532987 — IC50 = 120.1 nM 6.92
CHEMBL535079 — IC50 = 127.2 nM 6.90
CHEMBL601156 — IC50 = 129.4 nM 6.89
CHEMBL2028042 — IC50 = 136.9 nM 6.86
CHEMBL535730 — IC50 = 141.3 nM 6.85
CHEMBL475813 — IC50 = 156.2 nM 6.81
CHEMBL590435 — IC50 = 153.8 nM 6.81
CHEMBL530223 — IC50 = 158.1 nM 6.80
CHEMBL586704 — IC50 = 160.0 nM 6.80
CHEMBL597262 — IC50 = 158.3 nM 6.80
CHEMBL533563 — IC50 = 179.4 nM 6.75
CHEMBL532079 — IC50 = 180.6 nM 6.74
CHEMBL592550 — IC50 = 195.6 nM 6.71
CHEMBL548469 — IC50 = 196.7 nM 6.71
CHEMBL585622 — IC50 = 200.0 nM 6.70
CHEMBL261095 — IC50 = 201.7 nM 6.70
CHEMBL547476 — IC50 = 209.0 nM 6.68
CHEMBL592105 METHYLROSANILINE IC50 = 217.6 nM 6.66
CHEMBL124006 — IC50 = 236.8 nM 6.63
CHEMBL588855 — IC50 = 242.1 nM 6.62
CHEMBL532879 — IC50 = 241.6 nM 6.62
CHEMBL1545915 — IC50 = 239.4 nM 6.62
CHEMBL2028057 — IC50 = 262.8 nM 6.58
CHEMBL546799 — IC50 = 263.8 nM 6.58
CHEMBL547443 — IC50 = 271.7 nM 6.57
CHEMBL546162 — IC50 = 277.9 nM 6.56
CHEMBL587022 — IC50 = 283.1 nM 6.55
CHEMBL577014 — IC50 = 296.5 nM 6.53
CHEMBL585264 — IC50 = 298.3 nM 6.53
CHEMBL585243 — IC50 = 296.8 nM 6.53
CHEMBL1460047 — IC50 = 304.7 nM 6.52
CHEMBL598369 — IC50 = 302.4 nM 6.52
CHEMBL494669 — IC50 = 308.9 nM 6.51
CHEMBL578294 — IC50 = 311.4 nM 6.51
CHEMBL590674 — IC50 = 316.1 nM 6.50
CHEMBL591641 — IC50 = 314.4 nM 6.50
CHEMBL582072 — IC50 = 315.1 nM 6.50
CHEMBL427342 IMIDOCARB IC50 = 332.2 nM 6.48
CHEMBL531290 — IC50 = 337.7 nM 6.47
CHEMBL547488 — IC50 = 334.7 nM 6.47
CHEMBL602586 — IC50 = 345.3 nM 6.46
CHEMBL524784 — IC50 = 351.4 nM 6.45
CHEMBL582070 — IC50 = 365.1 nM 6.44
CHEMBL532155 — IC50 = 366.4 nM 6.44
CHEMBL2028055 — IC50 = 373.0 nM 6.43
CHEMBL579459 — IC50 = 369.5 nM 6.43