Assay Detail
Binding
CHEMBL3394957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of nuclear membrane mimetic lipid mixture
22
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.73 | 8.85 |
| Kd | 1 | 9.23 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27768 | — | — | 1 | 9.23 |
| CHEMBL137386 | — | — | 1 | 8.85 |
| CHEMBL3393748 | — | — | 1 | 8.52 |
| CHEMBL3393754 | — | — | 1 | 8.28 |
| CHEMBL3393750 | — | — | 1 | 8.04 |
| CHEMBL3393753 | — | — | 1 | 8.02 |
| CHEMBL3393752 | — | — | 1 | 7.89 |
| CHEMBL3393741 | — | — | 1 | 7.88 |
| CHEMBL230048 | — | — | 1 | 7.81 |
| CHEMBL3393745 | — | — | 1 | 7.77 |
| CHEMBL3393654 | — | — | 1 | 7.71 |
| CHEMBL3393743 | — | — | 1 | 7.70 |
| CHEMBL3393742 | — | — | 1 | 7.51 |
| CHEMBL3393746 | — | — | 1 | 7.47 |
| CHEMBL3393758 | — | — | 1 | 7.47 |
| CHEMBL3393749 | — | — | 1 | 7.46 |
| CHEMBL3393751 | — | — | 1 | 7.39 |
| CHEMBL3393756 | — | — | 1 | 7.39 |
| CHEMBL3393757 | — | — | 1 | 7.35 |
| CHEMBL3393747 | — | — | 1 | 7.33 |
| CHEMBL3393755 | — | — | 1 | 7.23 |
| CHEMBL3393744 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27768 | — | Kd | = | 0.59 | nM | 9.23 |
| CHEMBL137386 | — | Ki | = | 1.43 | nM | 8.85 |
| CHEMBL3393748 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3393754 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL3393750 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL3393753 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL3393752 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL3393741 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL230048 | — | Ki | = | 15.6 | nM | 7.81 |
| CHEMBL3393745 | — | Ki | = | 16.9 | nM | 7.77 |
| CHEMBL3393654 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL3393743 | — | Ki | = | 19.84 | nM | 7.70 |
| CHEMBL3393742 | — | Ki | = | 30.7 | nM | 7.51 |
| CHEMBL3393746 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL3393758 | — | Ki | = | 34.2 | nM | 7.47 |
| CHEMBL3393749 | — | Ki | = | 34.6 | nM | 7.46 |
| CHEMBL3393751 | — | Ki | = | 40.3 | nM | 7.39 |
| CHEMBL3393756 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3393757 | — | Ki | = | 45.1 | nM | 7.35 |
| CHEMBL3393747 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL3393755 | — | Ki | = | 58.8 | nM | 7.23 |
| CHEMBL3393744 | — | Ki | = | 63.0 | nM | 7.20 |