Assay Detail
Functional
CHEMBL3395148
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Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.46 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3394764 | — | — | 1 | 5.94 |
| CHEMBL3394763 | — | — | 1 | 5.72 |
| CHEMBL3394765 | — | — | 1 | 5.61 |
| CHEMBL3394762 | — | — | 1 | 5.50 |
| CHEMBL3394758 | — | — | 1 | 5.36 |
| CHEMBL3394759 | — | — | 1 | 5.27 |
| CHEMBL1672002 | THYMOQUINONE | 2.0 | 1 | 5.21 |
| CHEMBL3394767 | — | — | 1 | 5.06 |
| CHEMBL3394760 | — | — | 1 | - |
| CHEMBL3394761 | — | — | 1 | - |
| CHEMBL3394766 | — | — | 1 | - |
| CHEMBL3394768 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3394764 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL3394763 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL3394765 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL3394762 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL3394758 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL3394759 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL1672002 | THYMOQUINONE | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL3394767 | — | IC50 | = | 8790.0 | nM | 5.06 |
| CHEMBL3394760 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394761 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394766 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3394768 | — | IC50 | > | 10000.0 | nM | - |