Assay Detail
Binding
CHEMBL3395269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of dengue virus 2 NS2B-NS3 serine protease assessed as reduction in hydrolysis of Boc-Gly-Arg-Arg-7-amino-4-methylcumarin substrate by Dixon plot
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.63 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173475 | QUERCETIN DIHYDRATE | — | 1 | 4.68 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.65 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | 4.59 |
| CHEMBL82242 | QUERCITRIN | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173475 | QUERCETIN DIHYDRATE | Ki | = | 20700.0 | nM | 4.68 |
| CHEMBL150 | KAEMPFEROL | Ki | = | 22300.0 | nM | 4.65 |
| CHEMBL250450 | ISOQUERCETIN | Ki | = | 25900.0 | nM | 4.59 |
| CHEMBL82242 | QUERCITRIN | Ki | = | 25700.0 | nM | 4.59 |