Assay Detail
Binding
CHEMBL3395271
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Inhibition of dengue virus 3 NS2B-NS3 serine protease assessed as reduction in hydrolysis of Boc-Gly-Arg-Arg-7-amino-4-methylcumarin substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.56 | 4.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65320 | AGATHISFLAVONE | — | 1 | 4.76 |
| CHEMBL1173475 | QUERCETIN DIHYDRATE | — | 1 | 4.64 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.56 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.53 |
| CHEMBL82242 | QUERCITRIN | — | 1 | 4.50 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65320 | AGATHISFLAVONE | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1173475 | QUERCETIN DIHYDRATE | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL164 | MYRICETIN | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL82242 | QUERCITRIN | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL250450 | ISOQUERCETIN | IC50 | = | 42400.0 | nM | 4.37 |