Assay Detail
Binding
CHEMBL3395272
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Inhibition of dengue virus 3 NS2B-NS3 serine protease assessed as reduction in hydrolysis of Boc-Gly-Arg-Arg-7-amino-4-methylcumarin substrate by Dixon plot
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.62 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65320 | AGATHISFLAVONE | — | 1 | 4.82 |
| CHEMBL1173475 | QUERCETIN DIHYDRATE | — | 1 | 4.70 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.62 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.59 |
| CHEMBL82242 | QUERCITRIN | — | 1 | 4.55 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65320 | AGATHISFLAVONE | Ki | = | 15300.0 | nM | 4.82 |
| CHEMBL1173475 | QUERCETIN DIHYDRATE | Ki | = | 19900.0 | nM | 4.70 |
| CHEMBL150 | KAEMPFEROL | Ki | = | 24200.0 | nM | 4.62 |
| CHEMBL164 | MYRICETIN | Ki | = | 25700.0 | nM | 4.59 |
| CHEMBL82242 | QUERCITRIN | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL250450 | ISOQUERCETIN | Ki | = | 37100.0 | nM | 4.43 |