Assay Detail
Binding
CHEMBL3395317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PDE10A (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL4409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.59 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562318 | MARDEPODECT | 2.0 | 1 | 9.74 |
| CHEMBL19224 | PAPAVERINE | 3.0 | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562318 | MARDEPODECT | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL19224 | PAPAVERINE | IC50 | = | 36.0 | nM | 7.44 |