Assay Detail
Binding
CHEMBL3395401
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Antagonist activity at human OX1R by FLIPR assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.61 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107822 | FILOREXANT | 2.0 | 1 | 7.80 |
| CHEMBL3394842 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107822 | FILOREXANT | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3394842 | — | IC50 | = | 3908.0 | nM | 5.41 |