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Assay Detail

CHEMBL3395541

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh-5.2 cells assessed as decrease in HCV replicon RNA replication after 4 days by luciferase assay
ChEMBL ↗
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency.
Henderson JA, Bilimoria D, Bubenik M, Cadilhac C, Cottrell KM, Dietrich E, Denis F, Ewing N, Falardeau G, Giroux S, Grey R, L'Heureux L, Liu B, Mani N, Morris M, Nicolas O, Pereira OZ, Poisson C, Govinda Rao B, Reddy TJ, Selliah S, Shawgo RS, Vaillancourt L, Wang J, Yannopoulos CG, Chauret N, Berlioz-Seux F, Chan LC, Das SK, Grillot AL, Bennani YL, Maxwell JP.
Bioorg Med Chem Lett (2015) 25 : 944 -947
PubMed 25577041 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 10.34 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3121843 — — 1 11.00
CHEMBL3394855 — — 1 11.00
CHEMBL3394866 — — 1 10.96
CHEMBL3394853 — — 1 10.92
CHEMBL3121846 — — 1 10.92
CHEMBL3121853 — — 1 10.89
CHEMBL3394852 — — 1 10.89
CHEMBL3394857 — — 1 10.74
CHEMBL3394865 — — 1 10.72
CHEMBL3121958 — — 1 10.66
CHEMBL3121959 — — 1 10.62
CHEMBL3394867 — — 1 10.62
CHEMBL3394861 — — 1 10.51
CHEMBL3394860 — — 1 10.47
CHEMBL3394863 — — 1 10.43
CHEMBL3394849 — — 1 10.12
CHEMBL3394856 — — 1 10.09
CHEMBL3394859 — — 1 10.00
CHEMBL3394850 — — 1 7.70
CHEMBL3121957 — — 1 7.58
CHEMBL3394854 — — 1 -
CHEMBL3394851 — — 1 -
CHEMBL3394868 — — 1 -
CHEMBL3394858 — — 1 -
CHEMBL3394862 — — 1 -
CHEMBL3394864 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3121843 — EC50 = 0.01 nM 11.00
CHEMBL3394855 — EC50 = 0.01 nM 11.00
CHEMBL3394866 — EC50 = 0.011 nM 10.96
CHEMBL3394853 — EC50 = 0.012 nM 10.92
CHEMBL3121846 — EC50 = 0.012 nM 10.92
CHEMBL3121853 — EC50 = 0.013 nM 10.89
CHEMBL3394852 — EC50 = 0.013 nM 10.89
CHEMBL3394857 — EC50 = 0.018 nM 10.74
CHEMBL3394865 — EC50 = 0.019 nM 10.72
CHEMBL3121958 — EC50 = 0.022 nM 10.66
CHEMBL3121959 — EC50 = 0.024 nM 10.62
CHEMBL3394867 — EC50 = 0.024 nM 10.62
CHEMBL3394861 — EC50 = 0.031 nM 10.51
CHEMBL3394860 — EC50 = 0.034 nM 10.47
CHEMBL3394863 — EC50 = 0.037 nM 10.43
CHEMBL3394849 — EC50 = 0.076 nM 10.12
CHEMBL3394856 — EC50 = 0.082 nM 10.09
CHEMBL3394859 — EC50 = 0.1 nM 10.00
CHEMBL3394850 — EC50 = 20.0 nM 7.70
CHEMBL3121957 — EC50 = 26.0 nM 7.58
CHEMBL3394854 — EC50 = 0.006 nM -
CHEMBL3394851 — EC50 = 0.006 nM -
CHEMBL3394868 — EC50 = 0.005 nM -
CHEMBL3394858 — EC50 = 0.004 nM -
CHEMBL3394862 — EC50 = 0.007 nM -
CHEMBL3394864 — EC50 = 0.005 nM -