Assay Detail
Functional
CHEMBL3395587
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Neuroprotective activity in E14.5 rat embryo DRG neurons
11
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | DRG neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.66 | 7.34 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393337 | — | — | 1 | 7.34 |
| CHEMBL3393334 | — | — | 1 | 7.00 |
| CHEMBL3393333 | — | — | 2 | 6.97 |
| CHEMBL3393340 | — | — | 1 | 6.81 |
| CHEMBL3393327 | — | — | 1 | 6.77 |
| CHEMBL3393328 | — | — | 1 | 6.75 |
| CHEMBL3393332 | — | — | 1 | 6.40 |
| CHEMBL3393336 | — | — | 1 | 6.35 |
| CHEMBL3393335 | — | — | 1 | 6.16 |
| CHEMBL3393339 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393337 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3393334 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3393333 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3393340 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL3393327 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL3393328 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3393332 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL3393336 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL3393335 | — | IC50 | = | 697.0 | nM | 6.16 |
| CHEMBL3393339 | — | IC50 | = | 916.0 | nM | 6.04 |
| CHEMBL3393333 | — | Activity | - | — | - |