Assay Detail
Functional
CHEMBL3395859
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Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of diverse ACGs against multidrug resistant human lung cancer cell line A549/Taxol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.35 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL448616 | Squamostatin-D | — | 1 | 4.79 |
| CHEMBL506139 | — | — | 1 | 4.76 |
| CHEMBL448377 | Squamostatin-E | — | 1 | 4.54 |
| CHEMBL3394948 | — | — | 1 | 4.22 |
| CHEMBL3394949 | — | — | 1 | 4.21 |
| CHEMBL2228645 | REL-ANNOTEMOYIN-1 | — | 1 | 4.19 |
| CHEMBL3394952 | — | — | 1 | 4.12 |
| CHEMBL3394953 | — | — | 1 | 4.00 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | - |
| CHEMBL3394955 | — | — | 1 | - |
| CHEMBL3394954 | — | — | 1 | - |
| CHEMBL447119 | Squamostatin-A | — | 1 | - |
| CHEMBL484529 | ISODESACETYLUVARICIN | — | 1 | - |
| CHEMBL1933125 | UVARIGRANDIN A | — | 1 | - |
| CHEMBL3394951 | — | — | 1 | - |
| CHEMBL3394950 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL448616 | Squamostatin-D | IC50 | = | 16190.0 | nM | 4.79 |
| CHEMBL506139 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL448377 | Squamostatin-E | IC50 | = | 29170.0 | nM | 4.54 |
| CHEMBL3394948 | — | IC50 | = | 59880.0 | nM | 4.22 |
| CHEMBL3394949 | — | IC50 | = | 61940.0 | nM | 4.21 |
| CHEMBL2228645 | REL-ANNOTEMOYIN-1 | IC50 | = | 64920.0 | nM | 4.19 |
| CHEMBL3394952 | — | IC50 | = | 75880.0 | nM | 4.12 |
| CHEMBL3394953 | — | IC50 | = | 99360.0 | nM | 4.00 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 127090.0 | nM | - |
| CHEMBL3394955 | — | IC50 | = | 115900.0 | nM | - |
| CHEMBL3394954 | — | IC50 | = | 100430.0 | nM | - |
| CHEMBL447119 | Squamostatin-A | IC50 | > | 80000.0 | nM | - |
| CHEMBL484529 | ISODESACETYLUVARICIN | IC50 | > | 80000.0 | nM | - |
| CHEMBL1933125 | UVARIGRANDIN A | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394951 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL3394950 | — | IC50 | > | 120000.0 | nM | - |