Assay Detail
Binding
CHEMBL3395878
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Inhibition of PI3K p110delta (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.44 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152768 | — | — | 1 | 8.42 |
| CHEMBL1921986 | — | — | 1 | 7.85 |
| CHEMBL589258 | — | — | 1 | 7.85 |
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 7.43 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.31 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152768 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1921986 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL589258 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3393066 | VS-5584 | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL98350 | LY-294002 | IC50 | = | 1600.0 | nM | 5.80 |