Assay Detail
Binding
CHEMBL3395890
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.16 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393593 | — | — | 1 | 8.70 |
| CHEMBL589258 | — | — | 1 | 8.52 |
| CHEMBL1921986 | — | — | 1 | 7.77 |
| CHEMBL3393594 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393593 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL589258 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1921986 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3393594 | — | IC50 | = | 23.0 | nM | 7.64 |