Assay Detail
Functional
CHEMBL3396024
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Cytotoxicity against human U2OS cells assessed as cell viability after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Iterative conversion of cyclin binding groove peptides into druglike CDK inhibitors with antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.40 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393784 | — | — | 1 | 4.74 |
| CHEMBL3393783 | — | — | 1 | 4.51 |
| CHEMBL3393788 | — | — | 1 | 4.22 |
| CHEMBL3393786 | — | — | 1 | 4.12 |
| CHEMBL3393787 | — | — | 1 | - |
| CHEMBL3393785 | — | — | 1 | - |
| CHEMBL3393782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393784 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL3393783 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL3393788 | — | IC50 | = | 60500.0 | nM | 4.22 |
| CHEMBL3393786 | — | IC50 | = | 75600.0 | nM | 4.12 |
| CHEMBL3393787 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL3393785 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3393782 | — | IC50 | > | 100000.0 | nM | - |