Assay Detail
Binding
CHEMBL3396450
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Displacement of [125I]-Ang II from AT2 receptor in pig uterus myometrial membranes after 1.5 hrs by gamma-counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.38 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189568 | BULOXIBUTID | 0.5 | 1 | 9.40 |
| CHEMBL217673 | — | — | 1 | 9.15 |
| CHEMBL3394209 | — | — | 1 | 8.09 |
| CHEMBL3394208 | — | — | 1 | 8.00 |
| CHEMBL3394207 | — | — | 1 | 7.91 |
| CHEMBL2086892 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189568 | BULOXIBUTID | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL217673 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3394209 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL3394208 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL3394207 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL2086892 | — | Ki | = | 17.8 | nM | 7.75 |