Assay Detail
Binding
CHEMBL3396533
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Inhibition of Plasmodium vivax HGPRT
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium vivax |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.52 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3394327 | — | — | 1 | 8.00 |
| CHEMBL3394316 | — | — | 1 | 7.52 |
| CHEMBL3394313 | — | — | 1 | 7.40 |
| CHEMBL3394315 | — | — | 1 | 6.89 |
| CHEMBL2153480 | — | — | 1 | 6.52 |
| CHEMBL2153490 | — | — | 1 | 6.16 |
| CHEMBL3394312 | — | — | 1 | 5.80 |
| CHEMBL3394314 | — | — | 1 | 5.70 |
| CHEMBL3394311 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3394327 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3394316 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3394313 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3394315 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2153480 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2153490 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL3394312 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3394314 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3394311 | — | Ki | = | 20000.0 | nM | 4.70 |