Assay Detail
Functional
CHEMBL3396534
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Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H]-hypoxanthine incorporation after 96 hr
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.22 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3394318 | — | — | 1 | 6.00 |
| CHEMBL3394317 | — | — | 1 | 5.82 |
| CHEMBL3394319 | — | — | 1 | 5.68 |
| CHEMBL3394325 | — | — | 1 | 5.39 |
| CHEMBL3394324 | — | — | 1 | 5.22 |
| CHEMBL3394326 | — | — | 1 | 5.22 |
| CHEMBL3394328 | — | — | 1 | 5.19 |
| CHEMBL3394330 | — | — | 1 | 4.90 |
| CHEMBL3394329 | — | — | 1 | 4.62 |
| CHEMBL2153490 | — | — | 1 | 4.12 |
| CHEMBL2153480 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3394318 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3394317 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3394319 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3394325 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3394324 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3394326 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3394328 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3394330 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3394329 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2153490 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL2153480 | — | IC50 | = | 145000.0 | nM | - |