Assay Detail
Binding
CHEMBL3396577
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Inhibition of human recombinant MAO-B using p-tyramine as substrate assessed as H2O2 production after 15 mins by fluorescence assay
25
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.02 | 7.09 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3394533 | — | — | 1 | 7.09 |
| CHEMBL3394530 | — | — | 1 | 6.93 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 6.72 |
| CHEMBL3394537 | — | — | 1 | 6.66 |
| CHEMBL3394534 | — | — | 1 | 6.43 |
| CHEMBL3394529 | — | — | 1 | 6.41 |
| CHEMBL3394541 | — | — | 1 | 6.38 |
| CHEMBL3394531 | — | — | 1 | 6.32 |
| CHEMBL3394528 | — | — | 1 | 6.29 |
| CHEMBL3394542 | — | — | 1 | 6.27 |
| CHEMBL3394527 | — | — | 1 | 6.24 |
| CHEMBL574382 | — | — | 1 | 6.14 |
| CHEMBL3394532 | — | — | 1 | 6.08 |
| CHEMBL3394543 | — | — | 1 | 5.91 |
| CHEMBL3394535 | — | — | 1 | 5.89 |
| CHEMBL3394539 | — | — | 1 | 5.77 |
| CHEMBL3394526 | — | — | 1 | 5.72 |
| CHEMBL3394536 | — | — | 1 | 5.47 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.11 |
| CHEMBL3394544 | — | — | 1 | 5.03 |
| CHEMBL3394538 | — | — | 1 | 4.91 |
| CHEMBL3394540 | — | — | 1 | 4.70 |
| CHEMBL3394545 | — | — | 1 | - |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3394533 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3394530 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL673 | PARGYLINE | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3394537 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL3394534 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL3394529 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL3394541 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL3394531 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL3394528 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL3394542 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL3394527 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL574382 | — | IC50 | = | 723.0 | nM | 6.14 |
| CHEMBL3394532 | — | IC50 | = | 841.0 | nM | 6.08 |
| CHEMBL3394543 | — | IC50 | = | 1236.0 | nM | 5.91 |
| CHEMBL3394535 | — | IC50 | = | 1283.0 | nM | 5.89 |
| CHEMBL3394539 | — | IC50 | = | 1681.0 | nM | 5.77 |
| CHEMBL3394526 | — | IC50 | = | 1882.0 | nM | 5.72 |
| CHEMBL3394536 | — | IC50 | = | 3422.0 | nM | 5.47 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL3394544 | — | IC50 | = | 9334.0 | nM | 5.03 |
| CHEMBL3394538 | — | IC50 | = | 12320.0 | nM | 4.91 |
| CHEMBL3394540 | — | IC50 | = | 20080.0 | nM | 4.70 |
| CHEMBL3394545 | — | Inhibition | = | 46.42 | % | - |
| CHEMBL165 | RESVERATROL | IC50 | - | — | - | |
| CHEMBL140 | CURCUMIN | IC50 | - | — | - |