Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3396803

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human delta opioid receptor expressed in COS7 cells after 60 mins IP1 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type COS-7
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.
Sasmal PK, Krishna CV, Adabala SS, Roshaiah M, Rawoof KA, Thadi E, Sukumar KP, Cheera S, Abbineni C, Rao KV, Prasanthi A, Nijhawan K, Jaleel M, Iyer LR, Chaitanya TK, Tiwari NK, Krishna NL, Potluri V, Khanna I, Frimurer TM, Lückmann M, Rist Ø, Elster L, Högberg T.
Bioorg Med Chem Lett (2015) 25 : 887 -892
PubMed 25599839 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 5.61 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3394003 1 7.92
CHEMBL3394004 1 7.14
CHEMBL3394005 1 7.09
CHEMBL3394008 1 5.94
CHEMBL3393991 1 5.77
CHEMBL3393881 1 5.75
CHEMBL3394006 1 5.73
CHEMBL1449023 1 5.70
CHEMBL3394000 1 5.55
CHEMBL3393998 1 5.28
CHEMBL3393885 1 5.26
CHEMBL1488893 1 5.11
CHEMBL1190199 ASIMADOLINE 3.0 1 5.10
CHEMBL3394007 1 4.43
CHEMBL3393999 1 4.00
CHEMBL3393993 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3394003 EC50 = 12.0 nM 7.92
CHEMBL3394004 EC50 = 72.0 nM 7.14
CHEMBL3394005 EC50 = 82.0 nM 7.09
CHEMBL3394008 EC50 = 1150.0 nM 5.94
CHEMBL3393991 EC50 = 1700.0 nM 5.77
CHEMBL3393881 EC50 = 1800.0 nM 5.75
CHEMBL3394006 EC50 = 1850.0 nM 5.73
CHEMBL1449023 EC50 = 2000.0 nM 5.70
CHEMBL3394000 EC50 = 2800.0 nM 5.55
CHEMBL3393998 EC50 = 5200.0 nM 5.28
CHEMBL3393885 EC50 = 5500.0 nM 5.26
CHEMBL1488893 EC50 = 7800.0 nM 5.11
CHEMBL1190199 ASIMADOLINE EC50 = 8000.0 nM 5.10
CHEMBL3394007 EC50 = 37000.0 nM 4.43
CHEMBL3393999 EC50 = 100000.0 nM 4.00
CHEMBL3393993 EC50 = 100000.0 nM 4.00